EVOLUÇÃO DE MIELOFIBROSE E LEUCEMIA MIELOIDE AGUDA APÓS QUADRO CLÍNICO COMPATÍVEL COM DENGUE GRAVE: RELATO DE CASO

Mayko da Silva Botaro; André Cintra Bachega; José Eduardo Paes de Barros Greco Filho; Maria Eduarda Bernardino Sampaio; Lara Paula  Martins; Fernanda Claudia dos Santos Teixeira

doi:10.51891/rease.v11i11.22105

Authors

Mayko da Silva Botaro Conjunto Hospitalar do Mandaqui
André Cintra Bachega Conjunto Hospitalar do Mandaqui
José Eduardo Paes de Barros Greco Filho Conjunto Hospitalar do Mandaqui
Maria Eduarda Bernardino Sampaio Conjunto Hospitalar do Mandaqui
Lara Paula Martins Conjunto Hospitalar do Mandaqui
Fernanda Claudia dos Santos Teixeira Conjunto Hospitalar do Mandaqui

DOI:

https://doi.org/10.51891/rease.v11i11.22105

Keywords:

Dengue. Myelofibrosis. Acute myeloid leukemia. Inflammation. Bone marrow.

Abstract

We report the case of a 44-year-old female patient with metabolic comorbidities who presented a clinical picture compatible with severe dengue, without laboratory confirmation, and later developed pancytopenia, deep vein thrombosis, pulmonary embolism, and disseminated fungal infection. Bone marrow biopsy revealed hypercellularity with diffuse myeloid proliferation and increased angiogenesis, consistent with proliferative myelofibrosis. Days later, peripheral blood smear showed 87% blasts, characterizing acute leukemic transformation. This case raises the hypothesis that a systemic viral infection similar to dengue may act as an immunoinflammatory trigger for severe hematopoietic disorders such as myelofibrosis and acute myeloid leukemia.