SARS-COV-2 VIRULENCE MECHANISMS AND COMPLICATIONS IN THE PROGNOSIS OF PATIENTS WITH DIABETES MELLITUS: A LITERATURE REVIEW

Abstract

Introduction: Human Coronavirus infections have been known for decades, specifically, the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS). However, from 2019 onwards, a new coronavirus called SARS-CoV-2 has spread to several countries, taking an unprecedented proportion. From then on, with the huge increase in the number of infected and dead in different continents, resulting from the epidemic, in March 2020 the World Health Organization WHO officially decreed that the outbreak of the disease was a worldwide pandemic. Objective: To carry out a literature review about the virulence mechanisms of SARS-Cov-2, as well as its complications regarding the prognosis of patients with Diabetes Mellitus. Methodology: Electronic bibliographic searches were performed using descriptors previously selected in the Pubmed, Lilacs and Scielo databases that addressed the proposed theme in the period 2010 to 2021. Results: 08 articles were selected and the findings of the studies showed that the SARS-CoV- 2 ends up causing great consequences in patients with DM, as it provides an inflammatory environment that results in severe infections that are difficult to treat. Conclusion: Therefore, it can be seen that the metabolic inflammation caused by SARS-CoV-2 results in negative repercussions on the prognosis of patients with DM, thus hindering the individual's healing and recovery process, leading him to a worst outcome.