COMPARISON OF EPIDEMIOLOGICAL PROFILES OF PATIENTS WITH TESTICULAR CANCER AND KIDNEY CANCER VIA GENETIC PROFILE USING INTERNATIONAL DATABASE

Abstract

This study aimed to compare the epidemiological and genetic profiles of patients with testicular cancer and kidney cancer using data from the international platform The Human Protein Atlas. It is a retrospective observational study, analyzing genetic and demographic data from 133 patients with testicular cancer and 867 with renal cancer. The analysis revealed that testicular cancer predominantly affects young men (aged 20 to 40), while kidney cancer is more common in the elderly (over 60 years). In both neoplasms, most patients were of white ethnicity. Thirteen genes were identified as common between both types of cancer, with emphasis on BST2, IFI44, and HEXB, which showed unfavorable prognosis in both cases, suggesting their potential use as biomarkers. The study highlighted a possible genetic correlation between the two diseases, reinforcing the need for further research to better understand the relationship between these neoplasms, aiming to improve early diagnosis and develop personalized therapeutic strategies.

Keywords: Testicular cancer. Renal cancer.