THE APPLICATION OF THE CRISPR SYSTEM IN THE DEVELOPMENT OF A VACCINE AGAINST THE HIV-1 VIRUS

Abstract

The eradication of the human immunodeficiency virus (HIV) remains a significant global health challenge. HIV has posed a critical threat since its discovery, resulting in millions of deaths. Despite advances in treatment and prevention, a safe and effective vaccine remains crucial due to the high mutation rate of the virus, which generates several strains. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology appears to be a promising tool for developing an effective vaccine against HIV. The aim of this study is to investigate the feasibility and effectiveness of CRISPR-Cas9 gene editing in the development of an innovative vaccine against HIV-1. The methodology involves a literature review covering articles in English and Portuguese, as well as relevant books. The databases used include Scielo, PUBMED, Nature, AIDS Research and Human Retroviruses, and Journal of Virology, focusing on the most recent and relevant studies. The expected results include a detailed compilation of the mechanisms of action of CRISPR-Cas9 and its application in gene editing of HIV-1 infected cells. The review should provide new vaccination strategies using CRISPR technology to inactivate infection in immune cells.