NANOTECHNOLOGY: EFFECTS OF THE USE OF NANOPARTICLES IN NEURODEGENERATIVE DISEASES

Abstract

Objectives: In recent years, several studies have focused on the use of nanoparticles with bioactive compounds in the treatment of neurodegenerative diseases, since these bioactive compounds are capable of combating the deleterious effects of neuroinflammation and oxidative stress. Nanoparticles are an alternative for protecting compounds against proteolytic damage and improving their delivery efficiency and biological activity. The aim of this study is to carry out a literature review of data and test results using nanoparticles to combat neurodegenerative diseases. Methodology: Search sites such as PUBMED and SCIENCE were used, using the keywords: abstracts, nanoparticles, nanobiotechnology, neuroinflammation and bioactive compounds. Results: From the search we had good results on the use of nanoparticles in neurovegetative diseases, we highlight three relevant findings and according to the research we found a study on the effect of nanoparticles containing bioactive peptides on neuroinflammatory processes and oxidative stress, where they showed promising results, since bioactive peptides can fight neuroinflammation through interaction with immune receptors in brain cells and / or downstream inflammatory pathways. And also findings by Coelho, G (2019), in his experiments on the effect of indomethacin intercalated in double hydroxide lamellar nanoparticle (HDL) in a model of subacute neuroinflammation induced by lipopolysaccharide (LPS), was able to recover more quickly the deleterious effects induced by LPS. In another finding, Dewey, R (2024), tested gold nanoparticles and found a promising effect in reversing brain deficits in multiple sclerosis and Parkinson's disease. Conclusions: According to the studies, it can be seen that the use of nanoparticles to combat neurodegenerative effects is effective, since this literature review obtained relevant results through high-impact research proving its effectiveness. These findings contribute to advances in science and improvements in public health.