THE INFLUENCE OF VITAMIN B12 ON DEPRESSION AND THE PHARMACIST'S ROLE IN PATIENT FOLLOW-UP

Abstract

Depression is a multifactorial mental disorder that represents a serious public health problem, affecting millions of people worldwide. Recent scientific evidence indicates a possible association between vitamin B12 deficiency and the development or worsening of depressive symptoms, due to the essential role of this micronutrient in the formation of the myelin sheath and in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are fundamental for mood balance. A deficiency of this vitamin can raise homocysteine ​​levels, a neurotoxic substance associated with cognitive and emotional dysfunctions. In this context, the pharmacist plays a strategic role in the care of patients with depression, acting in the detection of nutritional deficiencies, promoting therapeutic adherence, and providing health education, which contributes to the effectiveness of treatment and the prevention of complications. This study aims to analyze the influence of vitamin B12 on depression and discuss the relevance of the pharmacist's role in the comprehensive care of patients. It has been found that vitamin B12 deficiency can worsen depressive symptoms and compromise mental well-being, with pharmaceutical follow-up being an effective strategy to optimize clinical outcomes and promote quality of life. Thus, the importance of multidisciplinary action and the integration between pharmacotherapy and nutritional care in the approach to mental health is reinforced.