POTENTIAL DRUG INTERACTIONS IN USERS OF AN ALCOHOL AND DRUG PSYCHOSOCIAL CARE CENTER IN THE INTERIOR OF BAHIA

Abstract

Potential Drug Interactions (PDIs) are pharmacological responses in which the effects of one or more drugs are altered by the simultaneous or previous administration of others, or by concurrent administration with food. This study aimed to identify and evaluate the main PDIs in pharmacotherapy among users treated at a Psychosocial Care Center (CAPS) in the interior of Bahia. This is a descriptive-analytical cross-sectional study, developed from the database of the Health Work Education Program (PET-Saúde), including medical records of patients assisted between 2020 and 2023 who simultaneously used two or more medications. Drugs were classified according to the World Health Organization's Anatomical Therapeutic Chemical (ATC) Classification, and data were analyzed using Excel and SPSS, version 21.0. PDIs were identified in 78.6% (110) of the possibilities evaluated, with an average of 1.41 PDIs per patient; the interaction between Diazepam and Fluoxetine was the most frequent (7.9%; 11 cases). Most of the drugs involved act on the nervous system, with Diazepam being the most common (17.4%; 42 PDIs). Monitoring PDIs can significantly reduce the risk of adverse effects, promoting better healthcare and quality of life for patients.