A IMPORTÂNCIA DO REVESTIMENTO ENTÉRICO EM CÁPSULAS

Abstract

The aim of this work was to analyze, through a literature review, the importance of enteric coating in capsules. The enteric coating is valuable for putting a barrier over a drug to keep it from dissolving through the stomach. The word enteric means to relate to or be inside the intestine. With an enteric coating, the drug is released depending on the pH value in the gastrointestinal tract which initiates the breakdown of the specific applied finish. The strategy of using pH as a trigger for the specific release of a product arises from learning how to change pH along the gastrointestinal tract. Some polymers are used to coat bored release films such as cellulosephthalate Acete, presenting a rapid dissolution at pH> 6, Hydroxyl propyl methyl cellulose phthalate that has imperceptible flavor is soluble in aqueous medium, with pH of 5.0 - 5.5, Hydroxyl acetate succinate propyl methyl cellulose being insoluble in acid medium, but soluble at neutral pH, Phthalate acetate insoluble in gastric fluids, but swells and quickly soluble in the upper part of the intestine and finally Metacrylic acid that allow the direction of specific areas of the intestine.  The type of study is a bibliographic review, research of this type has the primary objective of exposing the attributes of a given phenomenon or statement among its variables. Thus, it is recommended that it presents characteristics such as: analyzing the atmosphere as a direct source of data and the researcher as a switch instrument; not to broker the use of statistical artifices and methods, having as a greater apprehension the interpretation of phenomena and the imputation of results, the method should be the main focus for the approach and not the result or the fruit, the appreciation of the data should be achieved from intuitively and inductively through the researcher.