THE INFLUENCE OF BISPHOSPHONATES ON BONE REGENERATION IN IMPLANT SURGERIES

Abstract

Oral rehabilitation through implantology is an alternative used in tooth loss; however, for this treatment to be possible, factors such as the influence of systemic diseases and medications used by the patient need to be carefully verified. In this context, a group of widely used drugs are bisphosphonates (BFs), widely used to inhibit bone resorption and treat malignant neoplasms and directly influence the process of bone formation. The objective of the present study was to analyze, through an integrative literature review, the consequences of the use of bisphosphonates in the osseointegration of dental implants, with the following specific objectives: to present the physiology of bone repair in the osseointegration process of implants, to explain how the interference of bisphosphonates in the process of bone repair after surgery occurs and whether this relationship exists, and to mention the risks of installing implants in patients who use bisphosphonates. An integrative literature review was conducted based on articles found on the following platforms: Pubmed/Medline and Lilacs, of which 10 articles were selected due to their relevance to the topic. Current literature has shown a considerable success rate among patients who use bisphosphonates and receive dental implants. However, it is important that the dentist takes some precautions and warns the patient about the risks of implant loss and jaw necrosis due to the procedure performed. Bisphosphonates can act as an adjuvant in the treatment of patients undergoing oral surgical procedures in implantology.