ADVERSE EFFECTS OF NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH BREAST CANCER

Abstract

Neoadjuvant chemotherapy (NAC) is an essential therapeutic strategy in the treatment of breast cancer, aiming to reduce tumor size and improve surgical outcomes. Despite its efficacy, NAC is associated with a wide range of adverse effects that can significantly impact patients’ health and quality of life. This integrative review evaluated the main adverse effects related to NAC, including acute manifestations such as nausea, vomiting, fatigue, and alopecia, as well as subacute and chronic effects such as peripheral neuropathy and cardiotoxicity. Data analysis revealed that these effects not only affect physical health, but also have significant psychological and social implications. The review highlights the need for effective management strategies and supportive interventions to improve patients’ experience during treatment. Personalization of treatment regimens and the development of new therapeutic approaches are crucial to optimize clinical outcomes and quality of life.