ENDOCRINOLOGICAL APPROACH IN MODULATION OF IMMUNE RESPONSE: CURRENT PERSPECTIVES

Abstract

The endocrinological approach to modulating the immune response is a field of study that investigates the interaction between the endocrine system and the immune system. Understanding how endocrine hormones influence the immune response is essential for advances in the therapy of autoimmune, inflammatory and neoplastic diseases. Objective: The objective of this systematic literature review is to examine current perspectives on the endocrinological approach to modulating the immune response, highlighting the most recent findings and knowledge gaps. Methodology: The methodology was based on the PRISMA checklist. We used the PubMed, Scielo and Web of Science databases to search for articles published in the last 10 years. Descriptors included “endocrinology,” “immune response,” “hormones,” “cytokines,” and “modulation.” The inclusion criteria were original studies in English, Spanish or Portuguese, focused on the interaction between hormones and immune response. Exclusion criteria were duplicate studies, systematic reviews and studies focusing on fields other than endocrinology and immunology. Results: The results revealed a complex interaction between endocrine hormones and immune cells. Key topics included the role of cortisol in suppressing the immune response, the influence of thyroid hormones on immune function, and the impact of sex steroids on the inflammatory response. Furthermore, a variety of studies were found exploring endocrine therapies to modulate the immune response in different clinical contexts. Conclusion: In summary, the endocrinological approach to modulating the immune response offers valuable insights for understanding the physiological and pathological bases of the immune response. This review highlights the continued importance of research in this area and points to possible clinical applications for the development of new immunomodulatory therapies.