CLINICAL MANIFESTATIONS AND TREATMENT OF HEREDITARY HEART DISEASES: A GENETIC ANALYSIS

Abstract

Inherited heart disease constitutes a spectrum of conditions that affect millions and carry a significant burden on individuals and healthcare systems. Genetics plays a crucial role in the manifestation and progression of these diseases, and understanding the genetic variants involved has been fundamental to the development of personalized treatment strategies. Objective: The systematic review aimed to analyze clinical manifestations and evaluate therapeutic approaches for hereditary heart diseases, with an emphasis on the contribution of genetics to the diagnosis and management of these conditions. Methodology: The research was conducted according to the PRISMA checklist, using the PubMed, Scielo and Web of Science databases. Descriptors such as "hereditary heart diseases", "clinical manifestations", "genetic analysis", "treatment" and "therapeutic approaches" were used. Articles from the last ten years that included clinical studies, reviews and case reports were considered. Inclusion criteria covered studies with detailed genetic analysis, while studies without genetic data, opinion articles and publications without peer review were excluded. Results: 13 studies were selected. The results highlighted the heterogeneity of clinical manifestations and the importance of genetic analysis for an accurate diagnosis. Personalized treatments based on genetic profiling have shown promise in improving clinical outcomes. Conclusion: It was concluded that the integration of genetics in the evaluation and treatment of hereditary heart diseases is essential. Research has highlighted the need for personalized approaches to optimize clinical management and improve patients' quality of life.