ANTIOXIDANT THERAPIES IN THE MANAGEMENT OF ALZHEIMER'S DISEASE: AN INTEGRATIVE REVIEW

Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative condition characterized by progressive cognitive impairment and accumulation of amyloid plaques and neurofibrillary tangles. Antioxidant therapies have been studied as a potential approach to mitigate oxidative stress associated with AD pathogenesis. This integrative review aims to evaluate the efficacy of major antioxidant therapies in the management of AD, including vitamin E, coenzyme Q10, polyphenols, curcumin, and lipoic acid. Through the analysis of clinical trials, preclinical studies, and systematic reviews, diverse effects of these therapies were identified, with some showing neuroprotective potential and others showing limited clinical benefits. The results suggest that, although there is evidence of efficacy, the therapeutic effects of antioxidant interventions are variable and depend on factors such as formulation, dosage, and disease stage. Combining antioxidants with other therapeutic modalities may offer a more comprehensive approach to the treatment of AD. Future research is needed to standardize treatment protocols, explore underlying mechanisms, and evaluate the efficacy of antioxidant therapies in different patient subgroups.