CHRONIC MYELOID LEUKEMIA: A LITERARY REVIEW

Abstract

CML is characterized by the presence of the Philadelphia chromosome, due to chromosome translocation, where a fusion will occur between a portion of oneof the genes on chromosome 22 and another part of one of the genes on chromosome 9. In leukemia, diseased (cancer) blood cells form and disrupt the production of healthy bone marrow cells, decreasing their normalnumbers. Patients with CML have an overproduction of white blood cells and normally have a slow evolution in the growth of diseased cells over time, an approximate estimate of cases in the population, which is around 15% in adults, considering that there are other types of leukemia, this percentage receives a much greater weight, but in children the incidence is considered rare, corresponding to about 10% of all cases of CML.