ANALYSES OF THE MECHANISMS OF ACTION, APPLICATIONS, AND COMPLICATIONS OF OZONE THERAPY

Abstract

Ozone therapy has been widely studied and applied in therapeutic and aesthetic fields due to its antimicrobial, anti-inflammatory, and regenerative properties. However, despite the growing scientific and clinical interest, questions remain regarding the safety of the technique, the lack of standardized protocols, and the possible complications associated with its application, especially when performed without adequate professional training. In view of this issue, the general objective of the present study is to analyze the therapeutic and aesthetic applications of ozone therapy, with emphasis on its mechanisms of action and possible complications. This study consists of an integrative literature review, with a descriptive design and qualitative approach. The research will be conducted through a bibliographic survey in the PubMed, SciELO, Virtual Health Library (VHL), LILACS, and Google Scholar databases. Full-text articles published preferably within the last ten years, in Portuguese and English, and directly related to the topic will be included. Duplicate studies, publications outside the established time frame, studies not directly related to the topic, or those presenting low methodological rigor will be excluded. Data collection will be carried out through exploratory, selective, and analytical reading of the selected studies. The literature analysis is expected to demonstrate that ozone therapy has therapeutic and aesthetic potential related to the modulation of oxidative stress, antimicrobial activity, regulation of the inflammatory response, and tissue repair. Furthermore, it is expected to highlight methodological limitations and the lack of standardized protocols, factors that reinforce the need for professional training and further scientific studies to ensure greater safety and efficacy in the application of this technique.